Research and Development Executive

Job Description

Job Description

Job Purpose:

Hands-on experience in R&D, pilot-scale and plant-scale manufacturing batches, with a strong understanding of organic chemistry, reaction optimization, process development, scale-up, purification, analytical interpretation, and GMP manufacturing practices.

The role involves developing and optimizing chemical processes from laboratory scale through pilot/plant scale, troubleshooting process issues, improving yield and purity, and supporting technology transfer and manufacturing activities.

Key Responsibilities:

1. Process & Product Development

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• Develop, optimize, and establish robust chemical processes for pharmaceutical, API, specialty chemical, and fine chemical products.
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• Perform reaction route scouting, process optimization, and laboratory experimentation.
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• Optimize critical process parameters such as temperature, time, reagent/solvent quantity, concentration, pH, addition rate, agitation, and reaction conditions.
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• Evaluate process efficiency with respect to yield, purity, selectivity, cycle time, solvent consumption, and scalability.
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• Identify and troubleshoot process-related issues during development and scale-up.
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2. R&D and Scale-Up Activities:

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• Plan and execute laboratory R&D batches and process optimization experiments.
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• Demonstrate successful transition from gram scale to kilogram/pilot scale and plant scale.
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• Participate in pilot and commercial manufacturing batches and provide technical support during execution.
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• Monitor process performance during scale-up and identify potential scale-dependent issues.
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• Support process validation, process improvement, and troubleshooting activities.
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3. Purification & Isolation:

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• Hands-on experience in various purification and isolation techniques, including: Crystallization / precipitation, Fractional / vacuum distillation, Column chromatography, Impurity purge and control strategies
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• The candidate should be able to select and optimize suitable purification technology based on product properties, impurity profile, yield, scalability, and commercial feasibility.
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Skills Required

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1. Familiarity with standard organic reactions and laboratory practices.
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2. Experience in GMP manufacturing environments, GMP documentation and manufacturing practices.
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3. Good understanding of purification and basic analytical interpretation.
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4. Good understanding of HPLC, GC, GC-MS, LC-MS, NMR, IR, UV and melting point data.
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5. Interpret ¹H NMR and ¹³C NMR spectra for structure confirmation and impurity identification.
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6. Keen attention to detail and eagerness to learn from senior team members.
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7. Ability to work in a collaborative team environment and handle multiple lab tasks.
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8. Basic proficiency in using MS Office for documentation and report preparation
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9. Follow laboratory SOPs, EHS requirements, and chemical handling procedures
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10. Adhere to safety guidelines and responsible disposal of chemical waste.
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Technical/Functional Proficiency Required

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1. Proven track record of successful scale-up from lab to pilot/plant.
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2. Strong problem-solving mindset and ability to work in a fast-paced, project-driven environment.
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Educational Qualifications

M.Sc. in Organic / Industrial Chemistry or related field with strong synthetic lab exposure.

Experience Level (If applicable)

3–4 years of experience in chemical R&D or process development.